MAPK13 Antibody

• Background:

  P38 delta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

• NCBI Gene ID:

  5603

• Swiss Prot:

  O15264

• Accession Number:

  O15264

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Monkey

• Immunogen:

  This MAPK13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-365 amino acids from the C-terminal region of human MAPK13.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAPK13

• NCBI Official Name:

  Mitogen-activated protein kinase 13

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Duyndam, M.C., et al., J. Biol. Chem. 278 (9) :6885-6895 (2003) . Efimova, T., et al., J. Biol. Chem. 277 (35) :31753-31760 (2002) . Knebel, A., et al., EMBO J. 20 (16) :4360-4369 (2001) . Hu, M.C., et al., J. Biol. Chem. 274 (11) :7095-7102 (1999) . Parker, C.G., et al., Biochem. Biophys. Res. Commun. 249 (3) :791-796 (1998) .

• Other Product Names:

  Mitogen-activated protein kinase 13, MAP kinase 13, MAPK 13, Mitogen-activated protein kinase p38 delta, MAP kinase p38 delta, Stress-activated protein kinase 4, MAPK13, PRKM13, SAPK4

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid