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MAPK14 Antibody

CAT: 0223-62-979Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-979Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
NCBI Gene ID
1432
Swiss Prot
Q16539
Accession Number
Q16539
Host
Rabbit
Reactivity
Human
Immunogen
This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-324 amino acids from the C-terminal region of human MAPK14.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Symbol
MAPK14
NCBI Official Name
Mitogen-activated protein kinase 14
NCBI Organism
Homo sapiens
Background Reference 01
Cheung, P.C., et al., EMBO J. 22 (21) :5793-5805 (2003) .
Background Reference 02
Dean, J.L., et al., J. Biol. Chem. 278 (41) :39470-39476 (2003) .
Background Reference 03
Sun, A., et al., Exp. Neurol. 183 (2) :394-405 (2003) .
Background Reference 04
Yustein, J.T., et al., Oncogene 22 (40) :6129-6141 (2003) .
Other Product Names
Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a, MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Tested Applications
WB, IF, Flow
Physical Properties
Liquid

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MBS8515947-01MAPK14 Antibody

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