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Cdc6 Antibody

CAT: 0223-62-209Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-209Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human Cdc6 is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
NCBI Gene ID
990
Swiss Prot
Q99741
Accession Number
Q99741
Host
Rabbit
Reactivity
Human
Immunogen
This Cdc6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human Cdc6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CDC6
NCBI Official Name
Cell division control protein 6 homolog
NCBI Organism
Homo sapiens
Background Reference 01
Alexandrow, M.G., et al., Mol. Cell. Biol. 24 (4) :1614-1627 (2004) .
Background Reference 02
Yim, H., et al., Mol. Biol. Cell 14 (10) :4250-4259 (2003) .
Background Reference 03
Clay-Farrace, L., et al., EMBO J. 22 (3) :704-712 (2003) .
Background Reference 04
Pelizon, C., et al., EMBO Rep. 3 (8) :780-784 (2002) .
Other Product Names
Cell division control protein 6 homolog, CDC6-related protein, Cdc18-related protein, HsCdc18, p62 (cdc6), HsCDC6, CDC6, CDC18L
Tested Applications
WB
Protein ID
50400620
Physical Properties
Liquid

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