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NRG1 Antibody

CAT: 0223-62-185Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-185Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF) . They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
NCBI Gene ID
3084
Swiss Prot
Q02297
Accession Number
Q02297
Host
Rabbit
Reactivity
Human
Immunogen
This NRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-229 amino acids from the Central region of human NRG1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Symbol
NRG1
NCBI Official Name
Pro-neuregulin-1, membrane-bound isoform
NCBI Organism
Homo sapiens
Background Reference 01
Stove, C., et al., J. Invest. Dermatol. 121 (4) :802-812 (2003) .
Background Reference 02
Adelaide, J., et al., Genes Chromosomes Cancer 37 (4) :333-345 (2003) .
Background Reference 03
Ritch, P.A., et al., J. Biol. Chem. 278 (23) :20971-20978 (2003) .
Background Reference 04
Vermeer, P.D., et al., Nature 422 (6929) :322-326 (2003) .
Other Product Names
Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, Neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF, HGL, HRGA, NDF, SMDF
Tested Applications
WB, IHC-P, Flow
Protein ID
9297018
Physical Properties
Liquid

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