NRG2 Antibody

• Background :

  Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.

• NCBI Gene ID :

  9542

• Swiss Prot :

  O14511

• Accession Number :

  O14511

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This NRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  92 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  NRG2

• NCBI Official Name :

  Pro-neuregulin-2, membrane-bound isoform

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Yamada, K., et al., Gene 255 (1) :15-24 (2000) . Ring, H.Z., et al., Hum. Genet. 104 (4) :326-332 (1999) . Busfield, S.J., et al., Mol. Cell. Biol. 17 (7) :4007-4014 (1997) . Higashiyama, S., et al., J. Biochem. 122 (3) :675-680 (1997) . Carraway, K.L. III, et al., Nature 387 (6632) :512-516 (1997) .

• Other Product Names :

  Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin-1, DON-1, Neural- and thymus-derived activator for ERBB kinases, NTAK, NRG2, NTAK

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid