NRG3 Antibody

• Background:

  NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

• NCBI Gene ID:

  10718

• Swiss Prot:

  P56975

• Accession Number:

  P56975

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the Central region of human NRG3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  78 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NRG3

• NCBI Official Name:

  Pro-neuregulin-3, membrane-bound isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhang, D., et al., Proc. Natl. Acad. Sci. U.S.A. 94 (18) :9562-9567 (1997) .

• Other Product Names:

  Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3, Neuregulin-3, NRG-3, NRG3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  9789758

• Physical Properties:

  Liquid