NRG1 Beta 1 Recombinant Protein

• Background:

  NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF) . They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

• NCBI Gene ID:

  3084

• Swiss Prot:

  Q02297

• Accession Number:

  NP_039250.2

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology, Neuroscience

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  53.2 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 53.2 kDa. The protein migrates as 65-80 kDa and 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Neuregulin1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Britsch S. Adv Anat Embryol Cell Biol. 2007. 190:1-65.

• Background Reference 02:

  Talmage DA. Novartis Found Symp. 2008. 289:74-84.

• Background Reference 03:

  Orr-Urtreger A, et al. Proc Natl Acad Sci U S A. 1993. 90 (5) :1867-71.

• Other Product Names:

  NRG1 Beta 1, HRG1 beta 1, Neuregulin-1 beta 1, Neuregulin1 beta 1, NRG1, ARIA, GGF, HGL, HRGA, NDF, SMDF

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3