NRG1‑beta 1 Recombinant Protein

• Background:

  Pro-neuregulin-1, Neuregulin-1 beta 1 (NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

• NCBI Gene ID:

  3084

• Swiss Prot:

  Q02297-6

• Accession Number:

  Q02297-6

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction, Other

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 4mM HCl. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  26.9 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Neuregulin 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Pro-neuregulin-1, Neuregulin-1 beta 1, NRG1-beta 1, HRG1-beta 1, EGF, NRG1, GGF, HGL, HRGA, NDF, SMDF, HRG1‑beta 1

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3