MAGEC1 Antibody

• Background:

  MAGEC1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, thus is about 800 residues longer than the other MAGE proteins. This gene is expressed in a significant proportion of tumors of various histological types, whereas it is silent in normal tissues, except testis. The function of this gene is unknown.

• NCBI Gene ID:

  9947

• Swiss Prot:

  O60732

• Accession Number:

  O60732

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAGEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 849-880 amino acids from the C-terminal region of human MAGEC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  124 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAGEC1

• NCBI Official Name:

  Melanoma-associated antigen C1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jungbluth, A.A., et al., Int. J. Cancer 99 (6) :839-845 (2002) .

• Background Reference 02:

  Chen, Y.T., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (12) :6919-6923 (1998) .

• Background Reference 03:

  Lucas, S., et al., Cancer Res. 58 (4) :743-752 (1998) .

• Background Reference 04:

  Lim, S.H., et al., Eur. J. Haematol. 67 (5-6), 332-334 (2001) .

• Other Product Names:

  Melanoma-associated antigen C1, Cancer/testis antigen 71, CT71, MAGE-C1 antigen, MAGEC1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid