MAGEC1 Antibody

• Background :

  MAGEC1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, thus is about 800 residues longer than the other MAGE proteins. This gene is expressed in a significant proportion of tumors of various histological types, whereas it is silent in normal tissues, except testis. The function of this gene is unknown.

• NCBI Gene ID :

  9947

• Swiss Prot :

  O60732

• Accession Number :

  O60732

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MAGEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 849-880 amino acids from the C-terminal region of human MAGEC1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  124 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MAGEC1

• NCBI Official Name :

  Melanoma-associated antigen C1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Jungbluth, A.A., et al., Int. J. Cancer 99 (6) :839-845 (2002) .

• Background Reference 02 :

  Chen, Y.T., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (12) :6919-6923 (1998) .

• Background Reference 03 :

  Lucas, S., et al., Cancer Res. 58 (4) :743-752 (1998) .

• Background Reference 04 :

  Lim, S.H., et al., Eur. J. Haematol. 67 (5-6), 332-334 (2001) .

• Other Product Names :

  Melanoma-associated antigen C1, Cancer/testis antigen 71, CT71, MAGE-C1 antigen, MAGEC1

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid