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MAGEA3 Antibody

CAT: 0223-62-153Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-153Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
NCBI Gene ID
4102
Swiss Prot
P43357
Accession Number
P43357
Host
Rabbit
Reactivity
Human
Immunogen
This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
35 kDa
Fragment
Rabbit Ig
Symbol
MAGEA3
NCBI Official Name
Melanoma-associated antigen 3
NCBI Organism
Homo sapiens
Background Reference 01
Guo, J., et al., Exp. Mol. Pathol. 74 (2) :140-147 (2003) . Consogno, G., et al., Blood 101 (3) :1038-1044 (2003) . Rogner, U.C., et al., Genomics 29 (3) :725-731 (1995) . Gaugler, B., et al., J. Exp. Med. 179 (3) :921-930 (1994) . van der Bruggen, P., et al., Science 254 (5038) :1643-1647 (1991) .
Other Product Names
Melanoma-associated antigen 3, Antigen MZ2-D, Cancer/testis antigen 13, CT13, MAGE-3 antigen, MAGEA3, MAGE3
Tested Applications
WB, IHC-P, Flow
Protein ID
1170857
Physical Properties
Liquid

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