MAGEA1 Antibody

• Background:

  MAGEA1 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.

• NCBI Gene ID:

  4100

• Swiss Prot:

  P43355

• Accession Number:

  P43355

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAGEA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-173 amino acids from the Central region of human MAGEA1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAGEA1

• NCBI Official Name:

  Melanoma-associated antigen 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Suyama, T., et al., Leuk. Res. 26 (12) :1113-1118 (2002) .

• Background Reference 02:

  Mallon, A.M., et al., Genome Res. 10 (6) :758-775 (2000) .

• Background Reference 03:

  Rogner, U.C., et al., Genomics 29 (3) :725-731 (1995) .

• Background Reference 04:

  Schultz-Thater, E., et al., Int. J. Cancer 59 (3) :435-439 (1994) .

• Other Product Names:

  Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 11, CT11, MAGE-1 antigen, MAGEA1, MAGE1, MAGE1A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1170855

• Physical Properties:

  Liquid