Products for Research Use Only
RegisterLogin

MAGEA4 Antibody

CAT: 0223-8191-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-8191-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
MAGEA4 is a member of the melanoma-associated antigen family that consists of a number of antigens recognized by cytotoxic T lymphocytes (1) . MAGEA4 may serve as a target for antitumoral vaccination and may play a role in embryonal development and tumor transformation or aspects of tumor progression. It is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma and have been implicated in some hereditary disorders, such as dyskeratosis congenital (2-4) .
NCBI Gene ID
4103
Swiss Prot
P43358
Accession Number
NP_001011550
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Cancer
Purification
MAGEA4 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Buffer
MAGEA4 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MAGEA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Observed Molecular Weight
Multiple independent MAGEA4 antibodies also show a band at ~45 kDa
Fragment
IgG
Specificity
MAGEA4 antibody is human specific. At least four isoforms of MAGEA4 are known to exist.
Symbol
MAGEA4
Positive Control 2
Cat. No. 10-001 - Human Breast Tissue Slide
NCBI Official Name
Melanoma antigen family A, 4
NCBI Organism
Homo sapiens
Background Reference 01
Bhan S, Negi SS, Shao C, et al. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin. Cancer Res. 2011; 17:4267-76.
Background Reference 02
Bhan S, Chuang A, Negi SS, et al. MAGEA4 induces growth in normal oral keratinocytes by inhibiting growth arrest and apoptosis. Oncol. Rep. 2012; 28:1498-502.
Background Reference 03
Saito T, Wada H, Yamasaki M, et al. High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine. Vaccine, epub. 2014; S0264-410X (14) 01217-1.
Background Reference 04
Zhang QM, He SJ, Shen N, et al. Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target. Int. J. Clin. Exp. Pathol. 2014; 7:3918-27.
Other Product Names
Melanoma antigen family A4, MAGE4, MAGE-41, MAGE4A, MAGE-4 antigen, MAGE4B, MAGE-X2, MAGE-X2 antigen, Melanoma-associated antigen 4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
58530871
Physical Properties
Liquid

Related Products

CatalogName
8191PMAGEA4 Peptide
62-153MAGEA3 Antibody
62-152MAGEA1 Antibody
19-684MAGEA1 Antibody
30-161MAGEA1 Antibody
26-104MAGEA1 Antibody
62-154MAGEA6 Antibody
29-721MAGEA8 Antibody
28-906MAGEA9 Antibody
23-419MAGEA6 Antibody

Alternative Products

CatalogName
CSB-PA013330GA01HUMAGEA4 Antibody

Popular Products