MAGEA4 Antibody

• Background:

  MAGEA4 is a member of the melanoma-associated antigen family that consists of a number of antigens recognized by cytotoxic T lymphocytes (1) . MAGEA4 may serve as a target for antitumoral vaccination and may play a role in embryonal development and tumor transformation or aspects of tumor progression. It is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma and have been implicated in some hereditary disorders, such as dyskeratosis congenital (2-4) .

• NCBI Gene ID:

  4103

• Swiss Prot:

  P43358

• Accession Number:

  NP_001011550

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell, Cancer

• Purification:

  MAGEA4 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1202 - A431 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  MAGEA4 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  MAGEA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Observed Molecular Weight:

  Multiple independent MAGEA4 antibodies also show a band at ~45 kDa

• Fragment:

  IgG

• Specificity:

  MAGEA4 antibody is human specific. At least four isoforms of MAGEA4 are known to exist.

• Symbol:

  MAGEA4

• Positive Control 2:

  Cat. No. 10-001 - Human Breast Tissue Slide

• NCBI Official Name:

  Melanoma antigen family A, 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bhan S, Negi SS, Shao C, et al. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin. Cancer Res. 2011; 17:4267-76.

• Background Reference 02:

  Bhan S, Chuang A, Negi SS, et al. MAGEA4 induces growth in normal oral keratinocytes by inhibiting growth arrest and apoptosis. Oncol. Rep. 2012; 28:1498-502.

• Background Reference 03:

  Saito T, Wada H, Yamasaki M, et al. High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine. Vaccine, epub. 2014; S0264-410X (14) 01217-1.

• Background Reference 04:

  Zhang QM, He SJ, Shen N, et al. Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target. Int. J. Clin. Exp. Pathol. 2014; 7:3918-27.

• Other Product Names:

  Melanoma antigen family A4, MAGE4, MAGE-41, MAGE4A, MAGE-4 antigen, MAGE4B, MAGE-X2, MAGE-X2 antigen, Melanoma-associated antigen 4

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  58530871

• Physical Properties:

  Liquid