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CD46 Antibody

CAT: 0223-61-663Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-663Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD46 is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system.
NCBI Gene ID
4179
Swiss Prot
P15529
Accession Number
P15529
Host
Rabbit
Reactivity
Human
Immunogen
This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-343 amino acids from the C-terminal region of human CD46.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
CD46
NCBI Official Name
Membrane cofactor protein
NCBI Organism
Homo sapiens
Background Reference 01
Weyand, N.J., et al. J. Immunol. 184 (2) :694-701 (2010)
Background Reference 02
Santiago, C., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 1), 91-94 (2010)
Background Reference 03
Sullivan, M., et al. Ann. Hum. Genet. 74 (1) :17-26 (2010)
Background Reference 04
Lee, S.W., et al. J. Cell Biol. 156 (6) :951-957 (2002)
Other Product Names
Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
41019474
Physical Properties
Liquid

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