CD46 Antibody

• Background:

  CD46 is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system.

• NCBI Gene ID:

  4179

• Swiss Prot:

  P15529

• Accession Number:

  P15529

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-343 amino acids from the C-terminal region of human CD46.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD46

• NCBI Official Name:

  Membrane cofactor protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Weyand, N.J., et al. J. Immunol. 184 (2) :694-701 (2010)

• Background Reference 02:

  Santiago, C., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 1), 91-94 (2010)

• Background Reference 03:

  Sullivan, M., et al. Ann. Hum. Genet. 74 (1) :17-26 (2010)

• Background Reference 04:

  Lee, S.W., et al. J. Cell Biol. 156 (6) :951-957 (2002)

• Other Product Names:

  Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  41019474

• Physical Properties:

  Liquid