CD46 Recombinant Protein

• Background:

  Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) .

• NCBI Gene ID:

  4179

• Swiss Prot:

  P15529

• Accession Number:

  AAH30594.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  33.6 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  CD46 molecule, complement regulatory protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lublin D.M., et al., 1988, J. Exp. Med. 168:181-194.

• Background Reference 02:

  Astier A., et al., 2000, J. Immunol. 164:6091-6095.

• Background Reference 03:

  Noris M., et al., 2003, Lancet 362:1542-1547.

• Background Reference 04:

  Kemper C., et al., 2003, Nature 421:388-392.

• Other Product Names:

  CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3