CD40 Antibody

• Background:

  This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) . Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

• NCBI Gene ID:

  958

• Swiss Prot:

  P25942

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human CD40

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Immunology, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  B cells

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 42kDa

• Fragment:

  IgG

• Symbol:

  CD40

• Positive Control 2:

  293T

• Positive Control 3:

  SKOV3

• Positive Control 4:

  K-562

• Positive Control 5:

  Mouse lung

• Positive Control 6:

  Mouse liver

• NCBI Official Name:

  CD40 molecule, TNF receptor superfamily member 5

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid