ACO1 Antibody

CAT: 0223-61-255Size: 200 µLDry Ice: NoHazardous: No
CAT#:0223-61-255Size:200 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
NCBI Gene ID
48
Swiss Prot
P21399
Accession Number
P21399
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This ACO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 354-388 amino acids from the Central region of human ACO1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
98 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
ACO1
NCBI Official Name
Cytoplasmic aconitate hydratase
NCBI Organism
Homo sapiens
Background Reference 01
Hirling H., et al.Nucleic Acids Res. 20:33-39 (1992) .
Background Reference 02
Humphray S.J., et al.Nature 429:369-374 (2004) .
Background Reference 03
Mural R.J., et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Background Reference 04
Rouault T.A., et al.Proc. Natl. Acad. Sci. U.S.A. 87:7958-7962 (1990) .
Other Product Names
Cytoplasmic aconitate hydratase, Aconitase, 4.2.1.3, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1
Tested Applications
WB
Protein ID
3123225
Physical Properties
Liquid

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