ACO2 Antibody

• Background:

  ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification.

• NCBI Gene ID:

  50

• Swiss Prot:

  Q99798

• Accession Number:

  Q99798

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  This ACO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the Central region of human ACO2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  85 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ACO2

• NCBI Official Name:

  Aconitate hydratase, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Juang, H.H., Mol. Genet. Metab. 81 (3) :244-252 (2004) .

• Background Reference 02:

  Bota, D.A., et al., Nat. Cell Biol. 4 (9) :674-680 (2002) .

• Background Reference 03:

  Gruer, M.J., et al., Trends Biochem. Sci. 22 (1) :3-6 (1997) .

• Background Reference 04:

  Klausner, R.D., et al., Mol. Biol. Cell 4 (1) :1-5 (1993) .

• Other Product Names:

  Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase, ACO2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  6686275

• Physical Properties:

  Liquid