HLA-DQA2 Antibody

• Background:

  This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq].

• NCBI Gene ID:

  3118

• Swiss Prot:

  P01906

• Accession Number:

  P01906

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HLA-DQA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human HLA-DQA2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  HLA-DQA2

• NCBI Official Name:

  HLA class II histocompatibility antigen, DQ alpha 2 chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)

• Background Reference 02:

  Hor, H., et al. Nat. Genet. 42 (9) :786-789 (2010)

• Background Reference 03:

  Petukhova, L., et al. Nature 466 (7302) :113-117 (2010)

• Background Reference 04:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Other Product Names:

  HLA class II histocompatibility antigen, DQ alpha 2 chain, DX alpha chain, HLA class II histocompatibility antigen, DQ (6) alpha chain, HLA-DQA1, MHC class II DQA2, HLA-DQA2, HLA-DXA

• Tested Applications:

  WB

• Protein ID:

  122192

• Physical Properties:

  Liquid