HLA-DP + HLA-DQ + HLA-DR Antibody [CR3/43]

• Background:

  This mAb reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa) . They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some auto-immune diseases are associated with certain class II alleles.

• NCBI Gene ID:

  311531173119

• Swiss Prot:

  P04440, P01908, P01909, P01920, P01903

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human tonsil cells were used as the immunogen for the HLA-DP/DQ/DR antibody.

• Clonality:

  Monoclonal

• Clone:

  CR3/43

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  HLA-DPB1, HLA-DQA1

• NCBI Official Name:

  Major histocompatibility complex, class II, DP beta 1; major histocompatibility complex, class II, DQ alpha 1

• NCBI Organism:

  Homo sapiens

• Tested Applications:

  WB, IF, IHC-P

• Physical Properties:

  Liquid