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HLA-DRB4 Antibody

CAT: 0223-57-203Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-203Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
NCBI Gene ID
3126
Swiss Prot
P13762
Accession Number
P13762
Host
Rabbit
Reactivity
Human
Immunogen
This HLA-DRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human HLA-DRB4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HLA-DRB4
NCBI Official Name
HLA class II histocompatibility antigen, DR beta 4 chain
NCBI Organism
Homo sapiens
Background Reference 01
Awa, W.L., et al. Eur. J. Endocrinol. 163 (1) :97-104 (2010)
Background Reference 02
Christiansen, O.B., et al. J. Reprod. Immunol. 85 (1) :9-14 (2010)
Background Reference 03
Amoli, M.M., et al. Dis. Markers 28 (1) :49-53 (2010)
Background Reference 04
Gomez-Tortosa, E., et al. Dement Geriatr Cogn Disord 30 (1) :8-11 (2010)
Other Product Names
HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4
Tested Applications
WB
Protein ID
281371554
Physical Properties
Liquid

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