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HLA-DQA1 Antibody

CAT: 0223-56-257Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-257Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
NCBI Gene ID
1005094573117
Swiss Prot
P01909
Accession Number
P01909
Host
Rabbit
Reactivity
Human
Immunogen
This HLA-DQA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the N-terminal region of human HLA-DQA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Symbol
HLA-DQA1
NCBI Official Name
HLA class II histocompatibility antigen, DQ alpha 1 chain
NCBI Organism
Homo sapiens
Background Reference 01
Donaldson, P.T., et al. J. Hepatol. 53 (6) :1049-1053 (2010)
Background Reference 02
Noble, J.A., et al. Diabetes 59 (11) :2972-2979 (2010)
Background Reference 03
Ferreira, R.C., et al. Nat. Genet. 42 (9) :777-780 (2010)
Background Reference 04
Ovsyannikova, I.G., et al. PLoS ONE (7), E11806 (2010) :
Other Product Names
HLA class II histocompatibility antigen, DQ alpha 1 chain, DC-1 alpha chain, DC-alpha, HLA-DCA, MHC class II DQA1, HLA-DQA1
Tested Applications
WB, Flow
Protein ID
122188
Physical Properties
Liquid

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