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HLA-DPB1 Antibody

CAT: 0223-57-302Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-302Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
NCBI Gene ID
3115
Swiss Prot
P04440
Accession Number
P04440
Host
Rabbit
Reactivity
Human
Immunogen
This HLA-DPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the Central region of human HLA-DPB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
HLA-DPB1
NCBI Official Name
HLA class II histocompatibility antigen, DP beta 1 chain
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Yang, J.H., et al. Tissue Antigens 76 (4) :282-288 (2010)
Background Reference 03
Wang, P., et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24 (6) :261-263 (2010)
Background Reference 04
Ovsyannikova, I.G., et al. PLoS ONE (7), E11806 (2010) :
Other Product Names
HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP (W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B
Tested Applications
WB, IHC-P
Protein ID
122263
Physical Properties
Liquid

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