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NR3C1 Antibody

CAT: 0223-60-740Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-740Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
NCBI Gene ID
2908
Swiss Prot
P04150
Accession Number
P04150
Host
Rabbit
Reactivity
Human
Immunogen
This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-588 amino acids from the C-terminal region of human NR3C1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rabbit
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NR3C1
NCBI Official Name
Glucocorticoid receptor
NCBI Organism
Homo sapiens
Background Reference 01
Seitz, T., et al. J. Mol. Biol. 403 (4) :562-577 (2010)
Background Reference 02
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Background Reference 03
Sarzynski, M.A., et al. IntObes (Lond) (2010) In press :
Background Reference 04
Desrivieres, S., et al. Addict Biol (2010) In press :
Other Product Names
Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Tested Applications
WB
Protein ID
121069
Physical Properties
Liquid

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