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NR3C2 Antibody

CAT: 0223-59-019Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-019Size:400 µL
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Background
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
4306
Swiss Prot
P08235
Accession Number
P08235
Host
Rabbit
Reactivity
Human
Immunogen
This NR3C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human NR3C2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
107 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NR3C2
NCBI Official Name
Mineralocorticoid receptor
NCBI Organism
Homo sapiens
Background Reference 01
Van Leeuwen, N., et al. Hypertension 56 (5) :995-1002 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Bouma, E.M., et al. Behav. Genet. (2010) In press :
Background Reference 04
Bogdan, R., et al. Genes Brain Behav. 9 (6) :658-667 (2010)
Other Product Names
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2, NR3C2, MCR, MLR
Tested Applications
WB
Protein ID
126885
Physical Properties
Liquid

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