LIN7B Antibody

• Background:

  Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity) .

• NCBI Gene ID:

  64130

• Swiss Prot:

  Q9HAP6

• Accession Number:

  Q9HAP6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  23 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  LIN7B

• NCBI Official Name:

  Protein lin-7 homolog B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zucker, B., et al. J. Neuropathol. Exp. Neurol. 69 (9) :880-895 (2010)

• Background Reference 02:

  Lanktree, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 147B (6), 945-951 (2008) :

• Background Reference 03:

  Sudo, K., et al. Neurosci. Res. 56 (4) :347-355 (2006)

• Background Reference 04:

  Li, Z., et al. J. Biol. Chem. 281 (16) :11066-11073 (2006)

• Other Product Names:

  Protein lin-7 homolog B, Lin-7B, hLin7B, Mammalian lin-seven protein 2, MALS-2, Vertebrate lin-7 homolog 2, Veli-2, hVeli2, LIN7B, MALS2, VELI2

• Tested Applications:

  WB

• Protein ID:

  59798472

• Physical Properties:

  Liquid