LIN7C Antibody

CAT: 0223-25-801Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-25-801Size:100 µL
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Background
LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
NCBI Gene ID
55327
Swiss Prot
Q9NUP9
Accession Number
NP_060832
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LIN7C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store LIN7C antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
22 kDa
Applications Notes
LIN7C antibody can be used for detection of LIN7C by ELISA at 1:312500. LIN7C antibody can be used for detection of LIN7C by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
LIN7C
NCBI Official Name
Lin-7 homolog C (C. elegans)
NCBI Organism
Homo sapiens
Background Reference 01
Lanktree, M., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press.
Other Product Names
LIN7C, FLJ11215, LIN-7-C, LIN-7C, MALS-3, VELI3, MALS3
Tested Applications
ELISA, WB
Protein ID
8922944
Physical Properties
Liquid

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