LIN7A Antibody

CAT: 0223-59-062Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-062Size:400 µL
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Background
LIN7A plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
NCBI Gene ID
8825
Swiss Prot
O14910
Accession Number
O14910
Host
Rabbit
Reactivity
Human
Immunogen
This LIN7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-207 amino acids from the C-terminal region of human LIN7A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
LIN7A
NCBI Official Name
Protein lin-7 homolog A
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Lanktree, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 147B (6), 945-951 (2008) :
Background Reference 03
Bohl, J., et al. J. Biol. Chem. 282 (13) :9392-9400 (2007)
Background Reference 04
Dode, L., et al. J. Biol. Chem. 280 (47) :39124-39134 (2005)
Other Product Names
Protein lin-7 homolog A, Lin-7A, hLin-7, Mammalian lin-seven protein 1, MALS-1, Tax interaction protein 33, TIP-33, Vertebrate lin-7 homolog 1, Veli-1, LIN7A, MALS1, VELI1
Tested Applications
WB
Physical Properties
Liquid

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