CRYM Antibody

• Background:

  Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.

• NCBI Gene ID:

  1428

• Swiss Prot:

  Q14894

• Accession Number:

  Q14894

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This CRYM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the Central region of human CRYM.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CRYM

• NCBI Official Name:

  Ketimine reductase mu-crystallin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martins-de-Souza, D., et al.Psychiatr Res (2010) In press :

• Background Reference 02:

  Al-Kafaji, G., et al. Biochem. Biophys. Res. Commun. 391 (4) :1585-1591 (2010)

• Background Reference 03:

  Malinowska, K., et al. Prostate 69 (10) :1109-1118 (2009)

• Background Reference 04:

  Martins-de-Souza, D., et al.Psychiatr Res 43 (11) :978-986 (2009)

• Other Product Names:

  Ketimine reductase mu-crystallin, NADP-regulated thyroid-hormone-binding protein, CRYM, THBP

• Tested Applications:

  WB

• Protein ID:

  2498259

• Physical Properties:

  Liquid