CRY1 Antibody

• Background :

  This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.

• NCBI Gene ID :

  1407

• Swiss Prot :

  Q16526

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human CRY1 (NP_004066.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  Mouse testis

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 70kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  CRY1

• Positive Control 2 :

  Mouse eye

• Positive Control 3 :

  Rat testis

• Positive Control 4 :

  SW480

• NCBI Official Name :

  Cryptochrome circadian clock 1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  CRY1, Chryptochrome 1, Cryptochrome-1, Photolyase homolog 1, PHLL1

• Tested Applications :

  WB

• Physical Properties :

  Liquid