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Cry1 Antibody

CAT: 0223-62-136Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-136Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central ?gears?driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
NCBI Gene ID
1407
Swiss Prot
Q16526
Accession Number
Q16526
Host
Rabbit
Reactivity
Human
Immunogen
This Cry1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 556-586 amino acids from the C-terminal region of human Cry1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Symbol
CRY1
NCBI Official Name
Cryptochrome-1
NCBI Organism
Homo sapiens
Background Reference 01
Griffin, E.A. Jr., et al., Science 286 (5440) :768-771 (1999) .
Background Reference 02
Van der Horst, G.T., et al., Nature 398 (6728) :627-630 (1999) .
Background Reference 03
Kobayashi, K., et al., Nucleic Acids Res. 26 (22) :5086-5092 (1998) .
Background Reference 04
Hsu, D.S., et al., Biochemistry 35 (44) :13871-13877 (1996) .
Other Product Names
Cryptochrome-1, CRY1, PHLL1
Tested Applications
WB, IHC-P
Protein ID
74735764
Physical Properties
Liquid

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