CRY1 Antibody

• Background:

  Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

• NCBI Gene ID:

  12952

• Swiss Prot:

  Q16526

• Accession Number:

  NP_031797.1

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  CRY1 antibody was raised against a peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Mouse CRY1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  60 kDa

• Specificity:

  This antibody detects endogenous level of total CRY1 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  Cry1

• NCBI Official Name:

  Cryptochrome 1 (photolyase-like)

• NCBI Organism:

  This antibody was raised against a peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Mouse CRY1.

• Background Reference 01:

  Morioka N, et al. (2010) J Pharmacol Sci. 113 (3) : 234-45. Fonseca F, et al. (2010) Mol Diagn Ther. 14 (3) : 171-8. Stratmann M, et al. (2010) Genes Dev. 24 (12) : 1317-28.

• Other Product Names:

  Phll1, AU020726, AU021000, PHLL1

• Tested Applications:

  WB

• Protein ID:

  6681031

• Physical Properties:

  Liquid