KHDRBS3 Antibody

• Background:

  RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.

• NCBI Gene ID:

  10656

• Swiss Prot:

  O75525

• Accession Number:

  O75525

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KHDRBS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human KHDRBS3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KHDRBS3

• NCBI Official Name:

  KH domain-containing, RNA-binding, signal transduction-associated protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xin, X., et al. Genome Res. 19 (7) :1262-1269 (2009)

• Background Reference 02:

  Lu, Y., et al. PLoS ONE (7), E6159 (2009) :

• Background Reference 03:

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Background Reference 04:

  Schymick, J.C., et al. Lancet Neurol 6 (4) :322-328 (2007)

• Other Product Names:

  KH domain-containing, RNA-binding, signal transduction-associated protein 3, RNA-binding protein T-Star, Sam68-like mammalian protein 2, SLM-2, Sam68-like phosphotyrosine protein, KHDRBS3, SALP, SLM2

• Tested Applications:

  WB

• Physical Properties:

  Liquid