KHDRBS1 Antibody

• Background:

  KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. KHDRBS1 play a role in G2-M progression in the cell cycle. It represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. KHDRBS1 also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

• NCBI Gene ID:

  10657

• Swiss Prot:

  Q07666

• Accession Number:

  NP_006550

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KHDRBS1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cell Cycle, Signal Transduction, Immunology

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10407 - Fetal Heart Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KHDRBS1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  48 kDa

• Applications Notes:

  KHDRBS1 antibody can be used for detection of KHDRBS1 by ELISA at 1:12500. KHDRBS1 antibody can be used for detection of KHDRBS1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  KHDRBS1

• NCBI Official Name:

  KH domain containing, RNA binding, signal transduction associated 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Duran, A., (2008) Cancer Cell 13 (4), 343-354.

• Other Product Names:

  KHDRBS1, FLJ34027, Sam68, p62, p68

• Tested Applications:

  ELISA, WB

• Protein ID:

  5730027

• Physical Properties:

  Liquid