Mouse Khdrbs1 Antibody

• Background:

  Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

• NCBI Gene ID:

  20218

• Swiss Prot:

  Q60749

• Accession Number:

  Q60749

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Khdrbs1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-443 amino acids from the C-terminal region of mouse Khdrbs1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Human, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Khdrbs1

• NCBI Official Name:

  KH domain-containing, RNA-binding, signal transduction-associated protein 1

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Sette, C., et al. J. Androl. 31 (1) :66-74 (2010)

• Background Reference 02:

  Maroni, P., et al. Mol. Cell. Endocrinol. 309 (1-2), 26-31 (2009) :

• Background Reference 03:

  Paronetto, M.P., et al. J. Cell Biol. 185 (2) :235-249 (2009)

• Background Reference 04:

  Huot, M.E., et al. Mol. Cell. Biol. 29 (7) :1933-1943 (2009)

• Other Product Names:

  KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, Sam68, p21 Ras GTPase-activating protein-associated p62, p68, Khdrbs1 {ECO:0000312|MGI:MGI:893579}

• Tested Applications:

  WB

• Physical Properties:

  Liquid