MKL1 Antibody

• Background:

  The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

• NCBI Gene ID:

  57591

• Swiss Prot:

  Q969V6

• Accession Number:

  Q969V6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 497-525 amino acids from the Central region of human MKL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  99 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MKL1

• NCBI Official Name:

  MKL/myocardin-like protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gilles, L., et al. Blood 114 (19) :4221-4232 (2009)

• Background Reference 02:

  Hinohara, K., et al. Hum. Genet. 126 (4) :539-547 (2009)

• Background Reference 03:

  Estrada, K., et al. Hum. Mol. Genet. 18 (18) :3516-3524 (2009)

• Background Reference 04:

  Brandt, D.T., et al. Nat. Cell Biol. 11 (5) :557-568 (2009)

• Other Product Names:

  MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A, MKL1, KIAA1438, MAL

• Tested Applications:

  WB

• Protein ID:

  32363202

• Physical Properties:

  Liquid