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CD1B Antibody

CAT: 0223-59-909Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-909Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq].
NCBI Gene ID
910
Swiss Prot
P29016
Accession Number
P29016
Host
Rabbit
Reactivity
Human
Immunogen
This CD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human CD1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CD1B
NCBI Official Name
T-cell surface glycoprotein CD1b
NCBI Organism
Homo sapiens
Background Reference 01
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 02
Felio, K., et al. J. Exp. Med. 206 (11) :2497-2509 (2009)
Background Reference 03
Guiard, J., et al. J. Immunol. 182 (11) :7030-7037 (2009)
Background Reference 04
Cui, Y., et al. Biol. Direct 4, 47 (2009) :
Other Product Names
T-cell surface glycoprotein CD1b, CD1b, CD1B
Tested Applications
WB
Protein ID
115962
Physical Properties
Liquid

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