CRYBB3 Antibody

• Background:

  Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group) . Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. [provided by RefSeq].

• NCBI Gene ID:

  1417

• Swiss Prot:

  P26998

• Accession Number:

  P26998

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CRYBB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-207 amino acids from the C-terminal region of human CRYBB3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CRYBB3

• NCBI Official Name:

  Beta-crystallin B3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Muller, C., et al. Anim. Genet. 39 (1) :87-88 (2008)

• Background Reference 02:

  Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

• Background Reference 03:

  Riazuddin, S.A., et al. Invest. Ophthalmol. Vis. Sci. 46 (6) :2100-2106 (2005)

• Background Reference 04:

  Collins, J.E., et al. Genome Biol. (10), R84 (2004) :

• Other Product Names:

  Beta-crystallin B3, Beta-B3 crystallin, Beta-crystallin B3, N-terminally processed, CRYBB3, CRYB3

• Tested Applications:

  WB

• Protein ID:

  311033476

• Physical Properties:

  Liquid