CRYAB Antibody

CAT: 0223-15-156Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-15-156Size:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
1410
Swiss Prot
P02511
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human CRYAB (NP_001876.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
U-87MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 20kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CRYAB
Positive Control 2
293T
Positive Control 3
A-549
Positive Control 4
Mouse brain
Positive Control 5
Mouse heart
Positive Control 6
Mouse kidney
NCBI Official Name
Crystallin, alpha B
NCBI Organism
Homo sapiens
Other Product Names
CRYAB, CRYA2, CTPP2, HSPB5, MFM2, CMD1II, CTRCT16, HEL-S-101
Tested Applications
WB
Physical Properties
Liquid

Related Products

CatalogName
45-434PCRYAB Peptide
91-101CRYAB Recombinant Protein
58-323CRYGB Antibody
60-696CRYAA Antibody
19-816CRYAA Antibody
64-160WAS Antibody
13-349WAS Antibody
60-596WAS Antibody
63-408DGKB Antibody
63-412AK5 Antibody

Alternative Products

CatalogName
MBS850665-01CRYAB Antibody

Popular Products