CRYBB1 Antibody

• Background :

  Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group) . Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3.

• NCBI Gene ID :

  1414

• Swiss Prot :

  P53674

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human CRYBB1 (NP_001878.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  Affinity purification

• Positive Control :

  MCF7

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 36kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  CRYBB1

• Positive Control 2 :

  BT474

• NCBI Official Name :

  Crystallin beta B1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  CATCN3, CTRCT17, beta-crystallin B1, beta-B1 crystallin, eye lens structural protein

• Tested Applications :

  WB

• Physical Properties :

  Liquid