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CRYAB Antibody

CAT: 0223-57-208Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-208Size:400 µL
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Background
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
NCBI Gene ID
1410
Swiss Prot
P02511
Accession Number
P02511
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CRYAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-112 amino acids from the Central region of human CRYAB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Pig, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
20 kDa
Fragment
Rabbit Ig
Symbol
CRYAB
NCBI Official Name
Alpha-crystallin B chain
NCBI Organism
Homo sapiens
Background Reference 01
Martins-de-Souza, D., et al.Psychiatr Res 44 (14) :989-991 (2010)
Background Reference 02
Jehle, S., et al. Nat. Struct. Mol. Biol. 17 (9) :1037-1042 (2010)
Background Reference 03
Kida, E., et al. J. Neuropathol. Exp. Neurol. 69 (7) :745-759 (2010)
Background Reference 04
Deng, Y., et al. BMB Rep 43 (6) :432-437 (2010)
Other Product Names
Alpha-crystallin B chain, Alpha (B) -crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2
Tested Applications
WB, IHC-P
Protein ID
117385
Physical Properties
Liquid

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