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CLCNKA Antibody

CAT: 0223-59-194Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-194Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
1187
Swiss Prot
P51800
Accession Number
P51800
Host
Rabbit
Reactivity
Human
Immunogen
This CLCNKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human CLCNKA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
75 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLCNKA
NCBI Official Name
Chloride channel protein ClC-Ka
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 02
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 03
Kramer, B.K., et al. Nat Clin Pract Nephrol 4 (1) :38-46 (2008)
Background Reference 04
Martinez, G.Q., et al. PLoS ONE (7), E2746 (2008) :
Other Product Names
Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1, CLCNKA
Tested Applications
WB
Protein ID
1705857
Physical Properties
Liquid

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