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CLCN3 Antibody

CAT: 0223-58-987Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-987Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CLCN3 mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
NCBI Gene ID
1182
Swiss Prot
P51790
Accession Number
P51790
Host
Rabbit
Reactivity
Human
Immunogen
This CLCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-313 amino acids from the Central region of human CLCN3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLCN3
NCBI Official Name
H (+) /Cl (-) exchange transporter 3
NCBI Organism
Homo sapiens
Background Reference 01
Cuddapah, V.A., et al. J. Biol. Chem. 285 (15) :11188-11196 (2010)
Background Reference 02
Xiong, D., et al. Clin. Exp. Pharmacol. Physiol. 36 (4) :386-393 (2009)
Background Reference 03
Yin, Z., et al. Am. J. Physiol., Cell Physiol. 294 (2), C535-C542 (2008) :
Background Reference 04
Matsuda, J.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C251-C262 (2008) :
Other Product Names
H (+) /Cl (-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3, CLCN3
Tested Applications
WB
Protein ID
226693513
Physical Properties
Liquid

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