CLCN1 Antibody

• Background:

  The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen) . Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  1180

• Swiss Prot:

  P35523

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 779-988 of human CLCN1 (NP_000074.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 109kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  CLCN1

• Positive Control 2:

  Mouse liver

• NCBI Official Name:

  Chloride voltage-gated channel 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CLC1, chloride channel protein 1, chloride channel 1, skeletal muscle, chloride channel protein, skeletal muscle, chloride channel, voltage-sensitive 1, clC-1

• Tested Applications:

  WB

• Physical Properties:

  Liquid