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PPFIA1 Antibody

CAT: 0223-59-192Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-192Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI Gene ID
8500
Swiss Prot
Q13136
Accession Number
Q13136
Host
Rabbit
Reactivity
Human
Immunogen
This PPFIA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human PPFIA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
136 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PPFIA1
NCBI Official Name
Liprin-alpha-1
NCBI Organism
Homo sapiens
Background Reference 01
Asperti, C., et al. Exp. Cell Res. 316 (6) :915-926 (2010)
Background Reference 02
Dancau, A.M., et al. Genes Chromosomes Cancer 49 (1) :1-8 (2010)
Background Reference 03
Asperti, C., et al. J. Cell. Sci. 122 (PT 18), 3225-3232 (2009) :
Background Reference 04
Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)
Other Product Names
Liprin-alpha-1, LAR-interacting protein 1, LIP-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, PTPRF-interacting protein alpha-1, PPFIA1, LIP1
Tested Applications
WB
Protein ID
42558969
Physical Properties
Liquid