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PPFIA2 Antibody

CAT: 0223-59-296Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-296Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line.
NCBI Gene ID
8499
Swiss Prot
O75334
Accession Number
O75334
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PPFIA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-599 amino acids from the Central region of human PPFIA2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
143 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PPFIA2
NCBI Official Name
Liprin-alpha-2
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Background Reference 02
Ko, J., et al. J. Biol. Chem. 278 (43) :42377-42385 (2003)
Background Reference 03
Ko, J., et al. J. Neurosci. 23 (5) :1667-1677 (2003)
Background Reference 04
Fujinami, K., et al. Int. J. Mol. Med. 10 (2) :173-176 (2002)
Other Product Names
Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2, PPFIA2
Tested Applications
WB
Physical Properties
Liquid

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