PPFIBP1 Antibody

PPFIBP1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis.The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

8496

Q86W92-5

NP_803193

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PPFIBP1.

Unconjugated

Primary Antibodies

Cancer

Antibody is purified by protein A chromatography method.

Cat. No. 1205 - Jurkat Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PPFIBP1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

19 kDa, 113 kDa

PPFIBP1 antibody can be used for detection of PPFIBP1 by ELISA at 1:312500. PPFIBP1 antibody can be used for detection of PPFIBP1 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

PPFIBP1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

Homo sapiens

Kriajevska, M., (2002) J. Biol. Chem. 277 (7), 5229-5235.

PPFIBP1, L2, hSGT2, hSgt2p, SGT2

ELISA, WB

312032469