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HLA-DMB Antibody

CAT: 0223-58-561Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-561Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
NCBI Gene ID
3109
Swiss Prot
P28068
Accession Number
P28068
Host
Rabbit
Reactivity
Human
Immunogen
This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HLA-DMB
NCBI Official Name
HLA class II histocompatibility antigen, DM beta chain
NCBI Organism
Homo sapiens
Background Reference 01
Rinderknecht, C.H., et al. Immunology 131 (1) :18-32 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 03
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 04
Ferrante, A., et al. J. Immunol. 184 (3) :1153-1158 (2010)
Other Product Names
HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7
Tested Applications
WB
Protein ID
133160
Physical Properties
Liquid

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