GUCA2B Antibody

• Background:

  Uroguanylin and guanylin (GUCA2A; MIM 139392), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.

• NCBI Gene ID:

  2981

• Swiss Prot:

  Q16661

• Accession Number:

  Q16661

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GUCA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the C-terminal region of human GUCA2B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  12 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GUCA2B

• NCBI Official Name:

  Guanylate cyclase activator 2B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yoshikawa, Y., et al. Hypertens. Res. 30 (9) :789-796 (2007)

• Background Reference 02:

  Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35 (3) :233-236 (2007)

• Background Reference 03:

  Sindic, A., et al. Kidney Int. 67 (4) :1420-1427 (2005)

• Background Reference 04:

  Maake, C., et al. Histochem. Cell Biol. 119 (1) :69-76 (2003)

• Other Product Names:

  Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B

• Tested Applications:

  WB

• Protein ID:

  2495130

• Physical Properties:

  Liquid