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GUCA2B Antibody

CAT: 0223-58-458Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-458Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Uroguanylin and guanylin (GUCA2A; MIM 139392), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.
NCBI Gene ID
2981
Swiss Prot
Q16661
Accession Number
Q16661
Host
Rabbit
Reactivity
Human
Immunogen
This GUCA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the C-terminal region of human GUCA2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
12 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GUCA2B
NCBI Official Name
Guanylate cyclase activator 2B
NCBI Organism
Homo sapiens
Background Reference 01
Yoshikawa, Y., et al. Hypertens. Res. 30 (9) :789-796 (2007)
Background Reference 02
Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35 (3) :233-236 (2007)
Background Reference 03
Sindic, A., et al. Kidney Int. 67 (4) :1420-1427 (2005)
Background Reference 04
Maake, C., et al. Histochem. Cell Biol. 119 (1) :69-76 (2003)
Other Product Names
Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B
Tested Applications
WB
Protein ID
2495130
Physical Properties
Liquid

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