GUCY2D Antibody

• Background:

  This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].

• NCBI Gene ID:

  3000

• Swiss Prot:

  Q02846

• Accession Number:

  Q02846

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  This GUCY2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-570 amino acids from the Central region of human GUCY2D.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  120 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GUCY2D

• NCBI Official Name:

  Retinal guanylyl cyclase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

• Background Reference 02:

  Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

• Background Reference 03:

  Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)

• Background Reference 04:

  Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51 (5) :2608-2614 (2010)

• Other Product Names:

  Retinal guanylyl cyclase 1, RETGC-1, Guanylate cyclase 2D, retinal, Rod outer segment membrane guanylate cyclase, ROS-GC, GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  1345920

• Physical Properties:

  Liquid