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NEDD4L Antibody

CAT: 0223-58-119Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-119Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.
NCBI Gene ID
23327
Swiss Prot
Q96PU5
Accession Number
Q96PU5
Host
Rabbit
Reactivity
Mouse
Immunogen
This NEDD4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-604 amino acids from the Central region of human NEDD4L.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
112 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NEDD4L
NCBI Official Name
E3 ubiquitin-protein ligase NEDD4-like
NCBI Organism
Homo sapiens
Background Reference 01
Zhou, R., et al. J. Biol. Chem. 285 (40) :30523-30530 (2010)
Background Reference 02
Raikwar, N.S., et al. Am. J. Physiol. Renal Physiol. 299 (2), F436-F444 (2010) :
Background Reference 03
Hallows, K.R., et al. J. Biol. Chem. 285 (28) :21671-21678 (2010)
Background Reference 04
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Other Product Names
E3 ubiquitin-protein ligase NEDD4-like, 632-, NEDD42, Nedd4-2, NEDD4L, KIAA0439, NEDL3
Tested Applications
WB
Protein ID
73921204
Physical Properties
Liquid

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